Decreased Na+ flow into neuron

In some cells of the brain, when a small molecule called acetylcholine binds to Na+ channels those channels open and Na+ can enter the cell. In an experimental laboratory rat, you observe the rate of Na+ entering the cell is 50% less than normal. a) Identify as many ways as you can that could have caused this decrease in Na+ entering the cell. b) Explain how the ways you identified above could have caused this decrease in Na+ entering the cell.

Topics: 

Question Instructions: 

We recommend that you administer these questions as homework and preface the question with these instructions for students:

"For the following question, please respond to the best of your knowledge and using only the information in the question and what you know. Please do not refer to any outside sources (textbooks, notes, internet, etc.). Any reasonable attempt to answer the question will be awarded full credit."

Responses to this question can be analyzed for resistance ideas, gradient ideas, and/or using a Physiology Learning Progression Framework

To administer this question:

  1. Create a text question in your learning management system
  2. Copy the text and any images for the question from this web site and paste it into your learning management system.

To analyze resistance and gradient ideas:

1. Login to your account on this website
2. Return to this question
3. Click on the link below to Analyze resistance ideas
4. Upload your spreadsheet for analysis
5. Use the ‘Student Text Response Column (Start)’ dropdown menu to select the column containing the student responses to part a of the question.
6. Use the ‘Student Text Response Column (End)’ dropdown menu to select the column containing the student responses to part b of the question.
7. Both columns containing student responses should now be highlighted in teal
8. Add a note (e.g. pre-instruction) to your file if desired
9. Repeat steps 3 - 8 using the link below to Analyze gradient ideas

To analyze your class responses using a Physiology Learning Progression Framework:

1. Download the csv files from the gradient and resistance reports.
2. To a new file, copy and paste the entire resistance score column and gradient column into the same worksheet so that the student response is in column A, resistance score in column B and gradient score in column C. You should not need the values from the Probability columns.
3. Enter the formula below in the cells of column D.

=IF(SUM(B2,C2,D2)=3,4,IF(SUM(B2,C2,D2)=2,3,IF(SUM(B2,C2,D2)=1,2,1)))

Audience: 

Reports: 

thumbnail of small NSF logo in color without shading

This material is based upon work supported by the National Science Foundation (DUE grants: 1438739, 1323162, 1347740, 0736952 and 1022653). Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NSF.