Metabolic pathway flux – Enzyme dysfunction

Question text:

The pathway shown below depicts the conversion of thiamine phosphate to both isobutyryl-CoA (IB-CoA) and dimethylacryloyl-CoA (DMA-CoA).

Metabolic Pathway Flux

a.      Consider what happens if enzyme C doesn’t work anymore. Do you predict that this will affect flux through the pathway as a whole?

Yes, flux will be affected.

No, flux will not be affected.

b.      Provide a scientific explanation to support your prediction.

Background information:

This question was developed by Paula Lemons' BioSTEPs research group at the University of Georgia with funding from NSF DRL 1350345.



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This material is based upon work supported by the National Science Foundation (DUE grants: 1438739, 1323162, 1347740, 0736952 and 1022653). Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NSF.