Weak interactions and functional groups clicker sequence

Weak Interactions and Functional Groups Activity

Developed by: Jon Stoltzfus

Learning Objective:

"Students will be able to identify functional groups in various representations of biomolecules and predict how their properties influence the function of that biomolecule."

Textbook: Campbell 9e; Chapter 2 - 4: The Chemical Context of Life; Water and Life; and Carbon ahd the Molecular Diversity of Life

Connection to Vision and Change*
Core Concepts

1. Structure and Function:
Structural complexity, together with the information it provides, is built upon combinations of subunits that drive increasingly diverse and dynamic physiological responses in living organisms.

*Vision and Change: A Call to Action. Washington, DC: AAAS; 2010.  http://visionandchange.org/files/2011/03/Revised-Vision-and-Change-Final-Report.pdf


The goal of this activity is to have students think about the similarities and differences in the sturcuture of three molecules with which the students are familiar, urushiol (poison ivy, aspirin, and ibuprofen). Students are asked to identifiy similarities and differences in the stuctures of these moleucles and then apply basic conepts from the lecture to these molecules as the lecutre proceeds.  In the end, the students are asked, based on the similarties between these three molecules and their functions, to make predictions about how the drugs (aspirin and ibuprofen) might act specrically with their target (the COX enzyme).

Associated Questions

Functional group chemistry

Lecture slides with clicker questions1.5 MB

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This material is based upon work supported by the National Science Foundation (DUE grants: 1438739, 1323162, 1347740, 0736952 and 1022653). Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NSF.